About PREVALERG
Title: Optimizing The Prevention Methods For The Improvement Of Allergic Patient Management Efficiency (PREVALERG)
Duration: 27 months (18th sept. 2007 - 18th dec. 2009)
This project is financed by the National Authority for Scientific Research (NASR).
PREVALLERG project has the purpose to elaborate new prophylactic and therapeutic methods for allergic patients with respiratory diseases, based on a monitoring algorithm and by setting prevention procedures for exposure of aeroallergen sensitised persons. The theme is of national interest because allergic respiratory diseases are a major health problem worldwide, with dramatic increase of prevalence in the last decades, under the circumstances of major environmental changes and growth of aeroallergen sensitisation ratio.
The project aims to solve a complex problem (the role of allergens in the pathogenesis of some respiratory diseases), to create the mechanisms for implementation of prophylaxis measures, to develop new therapeutic tools and to monitor asthmatic and/or allergic rhinitis patients, in order to optimize the prevention methods and to improve the public health system.
In Romania there are no monitoring and prevention programs for allergic respiratory diseases and no exact data regarding the regional distribution of aeroallergens. As we noticed the growing trend of allergic respiratory diseases, in Romania should be also introduced new prevention methods at European standards. In order to set up a procedure for the better control of the disease, a study will be conducted on a pilot group of patients with asthma and/or allergic rhinitis, based on an IT system with a dedicated software that can be extended all over the country in order to integrate the results and to establish a standard for Romania.
To elaborate an evaluation algorithm based on a minimum number of tests there will be periodical clinical and functional evaluations, observing the dynamics of direct markers of allergic inflammation (specific IgE serum level, serum IL-4, IL-13, vs. IFN-?, NO in exhaled air), indirect markers (PC20 to methacholine), and rhino-manometeric tests. The main aeroallergens in the indoor environment and the airborne biotic particles will be identified for analyzing the dynamics of air pollen and its seasonal variation, creating annual pollen calendars for drawing a map of aeroallergens in the west of Romania.