PREVALERG Objectives
To reach this project general and specific objectives a multi-disciplinary consortium with complementary activities was set up by partners with expertise in immunology, allergology, aerobiology and clinicians, structured in 5 stages, for 27 months.
- Objective 1. (Stage I, sept.-dec. 2007)
- Objective 2. (Stage II, Jan.-June 2008)
- Objective 3. (Stage III, July-Dec.2008)
- Objective 4. (Stage IV, Jan.-June 2009)
- Objective 5. (Stage V, July-Dec. 2009)
Development of preliminary studies on respiratory allergic patients and environmental aeroallergen types characterization.
Stage results
1) Allergic patient selection and monitoring protocols;
2) Work protocols for aeroallergens evaluation and monitoring;
3) ALERGO BD electronic data base loaded with patients initial and monitoring information;
4) Web page.
Human dendritic cells response to pulsing with aeroallergens and pro-inflammatory mediators.
Stage results
1) Dendritic cells culture and differentiation technological procedure;
2) Dendritic cells and T CD4+ serum profiles (cytokines);
3) Lab methods; Analysis bulletins;
4) Research reports;
5) Scientific papers.
Studies on mechanisms of in vivo and in vitro allergic reactions in patients with respiratory pathology.
Stage results
1) Organ bath work protocol;
2) Analysis bulletins;
3) Western Romania annual pollen calendar;
4) ALERGO BD database filling in;
5) National symposium for results dissemination;
6) Symposium abstract volume;
7) Scientific reports;
8) Scientific papers published in BDI journals and communicated in scientific events.
Bronchial remodelling assessment process.
Stage results
1) Fibroblasts isolation and culture protocols from bronchial explants;
2) Myofibroblasts immunohistochemical characterisation;
3) Organization of postgraduate courses;
4) Courses;
5) Scientific reports;
6) Published papers in ISI Journals (1) and communications.
Respiratory allergic patients monitoring algorithm.
Stage results
1) ALERGO BD data base for allergic patients monitoring ;
2) Reference Centre for respiratory allergic diseases control;
3) Annual pollen calendar for western Romania;
4) Allergic patients guide;
5) Good practice guide for allergic diseases management;
6) Web site posted on UMFVBT server with multiple information;
7) Scientific reports;
8) Scientific works.
